{"id":239,"date":"2022-12-30T22:11:52","date_gmt":"2022-12-31T06:11:52","guid":{"rendered":"https:\/\/www.theranostec.com\/?page_id=239"},"modified":"2026-09-09T01:00:27","modified_gmt":"2026-09-09T08:00:27","slug":"home","status":"publish","type":"page","link":"https:\/\/www.theranostec.com\/","title":{"rendered":"Theranostec"},"content":{"rendered":"<p><script id=\"theranostec-page-favicon\">(function(){document.title=\"Theranostec | Precision nanomedicine for cancer therapy\";var icon=document.createElement(\"link\");icon.id=\"theranostec-preview-tab-icon\";icon.rel=\"icon\";icon.type=\"image\/png\";icon.href=\"https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-tab-icon-166ca0b3722e.png\";document.head.querySelectorAll('link[rel~=\"icon\"]').forEach(function(old){old.remove();});document.head.appendChild(icon);})();<\/script><br \/>\n<iframe class=\"theranostec-preview-frame\" title=\"Theranostec official website\" srcdoc=\"&lt;!doctype html&gt;&lt;html lang=&quot;en&quot;&gt;&lt;head&gt;&lt;meta charset=&quot;utf-8&quot;&gt;&lt;meta name=&quot;viewport&quot; 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font-size: .75rem; letter-spacing: .12em; text-transform: uppercase; }\n.pipeline-card h3 { margin: .55rem 0 .7rem; font-size: 1.2rem; }\n.pipeline-card p { margin: 0 0 1rem; color: #d9dedf; }\n.pipeline-card strong { color: #fffefa; }\n@media (max-width: 700px) { .pipeline-grid { grid-template-columns: 1fr; } }\n\n\/* Source-based technical briefs, 2026-09-04 *\/\n.program-fullname {font-weight:600; color:var(--ink); font-size:1.05rem; line-height:1.55; margin-bottom:1.1rem;}\n.technical-brief {margin-top:1.5rem; border-top:1px solid var(--line); padding-top:1rem;}\n.technical-brief summary {cursor:pointer; color:var(--navy); font-weight:600; padding:.4rem 0;}\n.technical-brief h4 {margin:1.3rem 0 .65rem; font-size:1rem;}\n.technical-brief p {font-size:.95rem;}\n.program .source-figure {grid-column:2 \/ -1; margin:1.5rem 0 0; background:#fff; padding:1rem; min-width:0;}\n.program .source-figure img {width:100%;height:auto;aspect-ratio:auto;object-fit:contain; max-height:none;}\n.program .source-figure figcaption {color:#53616d;background:#fff;padding:1rem 0 0;font-size:.8rem;line-height:1.6;letter-spacing:normal;}\n.source-figure figcaption a {display:inline-block;color:#245e74;text-decoration:underline;}\n@media(max-width:700px){.program .source-figure{grid-column:1 \/ -1;padding:.5rem;}.program-fullname{overflow-wrap:anywhere;}}\n.science-copy .autophagy-history {font-size:.92rem;line-height:1.65;} .autophagy-history a {color:inherit;text-decoration:underline;text-underline-offset:3px;}\n\/* User-supplied logo: display opaque artwork bounds without modifying its pixels. *\/\n.brand{width:14rem;padding:0;}\n.logo-window{position:relative;display:block;width:100%;aspect-ratio:1931 \/ 413;overflow:hidden;}\n.brand .logo-window img,.footer-grid .logo-window img{position:absolute;display:block;width:100.56965%;max-width:none;height:auto;padding:0;left:-.36251%;top:-37.28814%;}\n.footer-grid .logo-window{width:12rem;}\n@media(max-width:700px){.brand{width:11.5rem;}}\n\n\/* User-selected Company and Experimental Development illustrations. *\/\n#company .company-visual { grid-column: 1 \/ -1; min-width: 0; margin: 1.5rem 0 0; }\n#company .company-visual &gt; a, .program .experimental-visual &gt; a { display: block; }\n#company .company-visual img { display: block; width: 100%; height: auto; aspect-ratio: auto; object-fit: contain; }\n.program .experimental-visual { padding: 0; border: 0; background: transparent; }\n&lt;\/style&gt;&lt;\/head&gt;&lt;body&gt;\n  &lt;a class=&quot;skip-link&quot; href=&quot;#main&quot;&gt;Skip to content&lt;\/a&gt;\n  &lt;header class=&quot;site-header&quot; data-header&gt;\n    &lt;div class=&quot;nav-shell&quot;&gt;\n      &lt;a class=&quot;brand&quot; href=&quot;#top&quot; aria-label=&quot;Theranostec home&quot;&gt;\n        &lt;span class=&quot;logo-window&quot;&gt;&lt;img src=&quot;https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-logo-user-20260908.png&quot; alt=&quot;Theranostec&quot; width=&quot;1942&quot; height=&quot;809&quot;&gt;&lt;\/span&gt;\n      &lt;\/a&gt;\n      &lt;button class=&quot;menu-toggle&quot; type=&quot;button&quot; aria-expanded=&quot;false&quot; aria-controls=&quot;primary-navigation&quot;&gt;\n        &lt;span&gt;Menu&lt;\/span&gt;&lt;span class=&quot;menu-icon&quot; aria-hidden=&quot;true&quot;&gt;&lt;\/span&gt;\n      &lt;\/button&gt;\n      &lt;nav id=&quot;primary-navigation&quot; class=&quot;primary-nav&quot; aria-label=&quot;Primary navigation&quot;&gt;\n        &lt;a href=&quot;#science&quot;&gt;Science&lt;\/a&gt;\n        &lt;a href=&quot;#company&quot;&gt;Company&lt;\/a&gt;\n        &lt;a href=&quot;#programs&quot;&gt;Programs&lt;\/a&gt;\n        &lt;a href=&quot;#evidence&quot;&gt;Evidence &amp;amp; Updates&lt;\/a&gt;\n        &lt;a href=&quot;#contact&quot;&gt;Contact&lt;\/a&gt;\n        &lt;a class=&quot;nav-cta&quot; href=&quot;mailto:yli@theranostec.com?subject=Partnering%20with%20Theranostec&quot;&gt;Partner With Us&lt;\/a&gt;\n      &lt;\/nav&gt;\n    &lt;\/div&gt;\n  &lt;\/header&gt;\n\n  &lt;main id=&quot;main&quot;&gt;\n    &lt;section class=&quot;hero&quot; id=&quot;top&quot; aria-labelledby=&quot;hero-title&quot;&gt;\n      &lt;div class=&quot;hero-image&quot; role=&quot;img&quot; aria-label=&quot;Conceptual illustration of a folded cancer-cell surface with an intracellular lysosome\u2013autophagy cutaway and nanoparticles&quot;&gt;&lt;\/div&gt;\n      &lt;div class=&quot;hero-overlay&quot;&gt;&lt;\/div&gt;\n      &lt;div class=&quot;container hero-grid&quot;&gt;\n        &lt;div class=&quot;hero-copy&quot;&gt;\n          &lt;p class=&quot;eyebrow light&quot;&gt;Precision nanomedicine \u00b7 Cancer therapy&lt;\/p&gt;\n          &lt;h1 id=&quot;hero-title&quot;&gt;Precise.&lt;br&gt;Effective.&lt;br&gt;&lt;span&gt;Safe.&lt;\/span&gt;&lt;\/h1&gt;\n          &lt;p class=&quot;hero-lede&quot;&gt;Theranostec develops precision nanomedicines designed to improve both the delivery and effectiveness of cancer therapies.&lt;\/p&gt;\n          &lt;div class=&quot;button-row&quot;&gt;\n            &lt;a class=&quot;button button-primary&quot; href=&quot;#science&quot;&gt;Explore Our Science&lt;\/a&gt;\n            &lt;a class=&quot;button button-ghost&quot; href=&quot;#contact&quot;&gt;Partner With Us&lt;\/a&gt;\n          &lt;\/div&gt;\n        &lt;\/div&gt;\n        &lt;div class=&quot;hero-note&quot; aria-label=&quot;Development status&quot;&gt;\n          &lt;span class=&quot;note-index&quot;&gt;Current status&lt;\/span&gt;\n          &lt;strong&gt;Clinical development&lt;\/strong&gt;\n          &lt;p&gt;Promising anti-cancer effects have been reported in in vivo animal models.&lt;\/p&gt;\n        &lt;\/div&gt;\n      &lt;\/div&gt;\n    &lt;\/section&gt;\n\n    &lt;section class=&quot;glance&quot; aria-labelledby=&quot;glance-title&quot;&gt;\n      &lt;div class=&quot;container glance-grid&quot;&gt;\n        &lt;div&gt;\n          &lt;p class=&quot;eyebrow&quot;&gt;Company at a glance&lt;\/p&gt;\n          &lt;h2 id=&quot;glance-title&quot; class=&quot;sr-only&quot;&gt;Theranostec at a glance&lt;\/h2&gt;\n        &lt;\/div&gt;\n        &lt;dl class=&quot;metrics&quot;&gt;\n          &lt;div&gt;&lt;dt&gt;Focus&lt;\/dt&gt;&lt;dd&gt;Precision nanomedicine&lt;\/dd&gt;&lt;\/div&gt;\n          &lt;div&gt;&lt;dt&gt;Development&lt;\/dt&gt;&lt;dd&gt;Clinical development&lt;\/dd&gt;&lt;\/div&gt;\n          &lt;div&gt;&lt;dt&gt;Pipeline&lt;\/dt&gt;&lt;dd&gt;Two programs&lt;\/dd&gt;&lt;\/div&gt;\n          &lt;div&gt;&lt;dt&gt;Evidence&lt;\/dt&gt;&lt;dd&gt;Four selected publications&lt;\/dd&gt;&lt;\/div&gt;\n        &lt;\/dl&gt;\n      &lt;\/div&gt;\n    &lt;\/section&gt;\n\n    &lt;section class=&quot;section overview&quot; id=&quot;company&quot; aria-labelledby=&quot;overview-title&quot;&gt;\n      &lt;div class=&quot;container split-intro&quot;&gt;\n        &lt;div&gt;\n          &lt;p class=&quot;eyebrow&quot;&gt;Company overview&lt;\/p&gt;\n          &lt;h2 id=&quot;overview-title&quot;&gt;Translational cancer research centered on delivery and therapeutic effect.&lt;\/h2&gt;\n        &lt;\/div&gt;\n        &lt;div class=&quot;copy-column&quot;&gt;\n          &lt;p&gt;Theranostec develops precision nanomedicines that significantly improve both the delivery and effectiveness of cancer therapies.&lt;\/p&gt;\n          &lt;p&gt;The company is advancing its programs through clinical development. Its pipeline includes a program designated for clinical trials and a program at the IND stage.&lt;\/p&gt;\n          &lt;p&gt;Theranostec has received non-dilutive federal funding, including multiple Small Business Innovation Research Phase I and Phase II grants for optimization and IND-enabling studies.&lt;\/p&gt;\n        &lt;\/div&gt;\n        &lt;figure class=&quot;company-visual&quot;&gt;&lt;a href=&quot;https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-company-concept-041ce80b2c95.png&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot; aria-label=&quot;Open full-size company illustration&quot;&gt;&lt;img src=&quot;https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-company-concept-041ce80b2c95.png&quot; alt=&quot;Conceptual illustration of researchers collaborating in a laboratory with chemical synthesis, automated sample handling and computer-assisted molecular analysis.&quot; width=&quot;1774&quot; height=&quot;887&quot; loading=&quot;lazy&quot; decoding=&quot;async&quot;&gt;&lt;\/a&gt;&lt;\/figure&gt;\n      &lt;\/div&gt;\n    &lt;\/section&gt;\n\n    &lt;section class=&quot;section science&quot; id=&quot;science&quot; aria-labelledby=&quot;science-title&quot;&gt;\n      &lt;div class=&quot;container&quot;&gt;\n        &lt;div class=&quot;section-heading&quot;&gt;\n          &lt;p class=&quot;eyebrow&quot;&gt;Science&lt;\/p&gt;\n          &lt;h2 id=&quot;science-title&quot;&gt;Addressing treatment resistance through precision nanomedicine.&lt;\/h2&gt;\n        &lt;\/div&gt;\n        &lt;div class=&quot;science-grid&quot;&gt;\n          &lt;div class=&quot;science-copy&quot;&gt;\n &lt;p class=&quot;lead&quot;&gt;Autophagy is the cell\u2019s lysosome-dependent recycling process. In some cancers, tumor cells use this pathway to adapt to treatment stress, making autophagy a research target in treatment resistance.&lt;\/p&gt;\n &lt;p&gt;Theranostec integrates nanotechnology, medicinal chemistry and artificial intelligence (AI) to develop BAQ-based nano-autophagy inhibitors. Bisaminoquinoline (BAQ) chemistry combines lysosomal accumulation with molecular self-assembly; lipid nanoparticle (LNP) formulations support the development of selected BAQ candidates.&lt;\/p&gt;\n &lt;p&gt;The research strategy investigates disruption of acidic lysosomal function and impairment of late-stage autophagic degradation. Experimental evaluation connects lysosome\u2013autophagy engagement with drug delivery, formulation behavior and cancer-cell responses.&lt;\/p&gt;\n &lt;p class=&quot;autophagy-history&quot;&gt;The foundational importance of autophagy was recognized by the &lt;a href=&quot;https:\/\/www.nobelprize.org\/prizes\/medicine\/2016\/press-release\/&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;2016 Nobel Prize in Physiology or Medicine&lt;\/a&gt;, awarded to Yoshinori Ohsumi for discovering its mechanisms.&lt;\/p&gt;\n &lt;div class=&quot;science-callout&quot;&gt;&lt;span&gt;Research direction&lt;\/span&gt;&lt;p&gt;Investigating nano-autophagy inhibition to address treatment resistance and persistent cancer-cell states.&lt;\/p&gt;&lt;\/div&gt;\n &lt;\/div&gt;\n &lt;figure class=&quot;figure-card&quot;&gt;\n            &lt;a href=&quot;https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-science-autophagy-341fb3f63cf6.png&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot; aria-label=&quot;Open full-size BAQ nanomedicine mechanism diagram&quot;&gt;&lt;img src=&quot;https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-science-autophagy-341fb3f63cf6.png&quot; alt=&quot;Conceptual diagram of BAQ-based nanomedicine self-assembly, cellular uptake, endolysosomal trafficking, lysosomal dysfunction and impaired late-stage autophagic degradation.&quot; width=&quot;1536&quot; height=&quot;1024&quot; loading=&quot;lazy&quot;&gt;&lt;\/a&gt;\n            \n          &lt;\/figure&gt;\n        &lt;\/div&gt;\n      &lt;\/div&gt;\n    &lt;\/section&gt;\n\n    &lt;section class=&quot;section programs&quot; id=&quot;programs&quot; aria-labelledby=&quot;programs-title&quot;&gt;\n      &lt;div class=&quot;container&quot;&gt;\n        &lt;div class=&quot;section-heading compact&quot;&gt;\n          &lt;p class=&quot;eyebrow&quot;&gt;Programs&lt;\/p&gt;\n          &lt;h2 id=&quot;programs-title&quot;&gt;AI-guided design, structure-aware evidence and experimental development.&lt;\/h2&gt;\n        &lt;\/div&gt;\n\n        &lt;article class=&quot;program program-featured&quot; id=&quot;orion-baq&quot;&gt;\n &lt;div class=&quot;program-index&quot;&gt;01&lt;\/div&gt;\n &lt;div class=&quot;program-title&quot;&gt;&lt;p class=&quot;program-kicker&quot;&gt;AI-guided nanomedicine design&lt;\/p&gt;&lt;h3&gt;ORION-BAQ&lt;\/h3&gt;&lt;span class=&quot;status-pill&quot;&gt;Candidate design &amp;amp; optimization&lt;\/span&gt;&lt;\/div&gt;\n &lt;div class=&quot;program-body&quot;&gt;&lt;p class=&quot;program-fullname&quot;&gt;Optimization and Ranking Intelligence for Oncology Nanomedicine for BAQ&lt;\/p&gt;\n &lt;p&gt;ORION-BAQ is a scaffold-preserving, AI-guided workflow for designing and prioritizing bisaminoquinoline (BAQ) candidates. It connects modular medicinal chemistry with BAQ-series measurements, public drug-discovery resources and experimental feedback to guide the selection of compounds for synthesis and testing.&lt;\/p&gt;\n &lt;ul class=&quot;clean-list&quot;&gt;&lt;li&gt;Scaffold-preserving design across aminoquinoline heads, linkers, basic amines, hydrophobic tails and polarity modifications.&lt;\/li&gt;&lt;li&gt;Integrated interpretation of potency, toxicity risk, developability and lysosome\u2013autophagy evidence.&lt;\/li&gt;&lt;li&gt;Traceable nominations with uncertainty, chemical-neighbor context and feedback from measured results.&lt;\/li&gt;&lt;\/ul&gt;\n &lt;details class=&quot;technical-brief&quot;&gt;&lt;summary&gt;Read the technical brief&lt;\/summary&gt;&lt;div&gt;\n &lt;h4&gt;From chemical space to testable candidates&lt;\/h4&gt;&lt;p&gt;The workflow relates the established BAQ13 scaffold and the second-generation BAQ42 anchor to a chemically bounded analog space. BAQ-tuned models and source-linked evidence support the selection of synthetically accessible candidates while exposing tradeoffs among potency, mechanism retention and material properties.&lt;\/p&gt;\n &lt;h4&gt;Design, test and learn&lt;\/h4&gt;&lt;p&gt;The pancreatic-cancer research plan proposes testing candidate activity in chemotherapy-persistent cells and patient-derived models, including regrowth after treatment removal. The prostate-cancer research plan connects iterative candidate nomination and synthesis with formulation, cell and organoid testing, followed by pharmacokinetic and in vivo evaluation.&lt;\/p&gt;\n &lt;p&gt;These are research and validation plans. Candidate advancement depends on measured activity, selectivity, lysosome\u2013autophagy engagement, formulation behavior and exposure. Computational rankings guide nomination; they do not establish clinical efficacy.&lt;\/p&gt;&lt;\/div&gt;&lt;\/details&gt;&lt;\/div&gt;\n &lt;figure class=&quot;program-visual source-figure&quot;&gt;&lt;a href=&quot;https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-orion-baq-12206cf5efae.png&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot; aria-label=&quot;Open full-size diagram&quot;&gt;&lt;img src=&quot;https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-orion-baq-12206cf5efae.png&quot; alt=&quot;ORION-BAQ workflow showing scaffold-preserving analog construction and a BAQ-tuned evidence layer&quot; loading=&quot;lazy&quot;&gt;&lt;\/a&gt;&lt;\/figure&gt;&lt;\/article&gt;\n\n        &lt;article class=&quot;program program-reserved&quot; id=&quot;spei-pharm&quot;&gt;\n &lt;div class=&quot;program-index&quot;&gt;02&lt;\/div&gt;\n &lt;div class=&quot;program-title&quot;&gt;&lt;p class=&quot;program-kicker&quot;&gt;Structure-aware AI research&lt;\/p&gt;&lt;h3&gt;SPEI-Pharm&lt;\/h3&gt;&lt;span class=&quot;status-pill muted&quot;&gt;Research-stage&lt;\/span&gt;&lt;\/div&gt;\n &lt;div class=&quot;program-body&quot;&gt;&lt;p class=&quot;program-fullname&quot;&gt;Structure-Pocket Evidence Integration for Pharmacophore-guided scaffold triage&lt;\/p&gt;\n &lt;p&gt;SPEI-Pharm is a rule-constrained AI\/ML evidence-reasoning layer for prioritizing molecular scaffold families. An investigator-configured large language model (LLM) agent orchestrates deterministic structure-analysis tools and assembles source-linked evidence packets for synthesis planning and experimental review.&lt;\/p&gt;\n &lt;ul class=&quot;clean-list&quot;&gt;&lt;li&gt;Atom mapping, pose quality control and pharmacophore-feature annotation.&lt;\/li&gt;&lt;li&gt;Interaction normalization and attribution of molecular features to protein-pocket residues.&lt;\/li&gt;&lt;li&gt;Pocket-role, exposure, risk and modifiable-vector interpretation.&lt;\/li&gt;&lt;li&gt;Scaffold-family evidence packets for synthesis readiness and biochemical feedback.&lt;\/li&gt;&lt;\/ul&gt;\n &lt;details class=&quot;technical-brief&quot;&gt;&lt;summary&gt;Read the technical brief&lt;\/summary&gt;&lt;div&gt;\n &lt;h4&gt;Auditable structure\u2013pocket reasoning&lt;\/h4&gt;&lt;p&gt;SPEI-Pharm integrates existing molecule, pose and interaction evidence. It connects feature-level geometry and residue contacts to scaffold-family interpretation, so reviewers can trace a prioritization decision back to its supporting analysis.&lt;\/p&gt;\n &lt;h4&gt;Evidence quality and experimental follow-up&lt;\/h4&gt;&lt;p&gt;Schema and evidence gates preserve pass, warn, fail and unresolved states. Unsupported or conflicting tool outputs remain explicit uncertainties. The research plan uses a ROR\u03b3t scaffold-triage prototype to develop reusable evidence standards and proposes biochemical and cellular testing with matched docking-score-only comparators.&lt;\/p&gt;\n &lt;p&gt;The proposed validation evaluates decision quality, interpretability and synthesis readiness. Structure-based hypotheses do not independently demonstrate binding, affinity, efficacy, mechanism or pharmacology; those conclusions require experimental evidence.&lt;\/p&gt;&lt;\/div&gt;&lt;\/details&gt;&lt;\/div&gt;\n &lt;figure class=&quot;program-visual source-figure&quot;&gt;&lt;a href=&quot;https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-spei-pharm-workflow-20260904.png&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot; aria-label=&quot;Open full-size diagram&quot;&gt;&lt;img src=&quot;https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-spei-pharm-workflow-20260904.png&quot; alt=&quot;SPEI-Pharm panels A to D showing quality gates, feature mapping, pocket-role reasoning, scaffold triage and biochemical feedback&quot; loading=&quot;lazy&quot;&gt;&lt;\/a&gt;&lt;\/figure&gt;&lt;\/article&gt;\n\n        &lt;article class=&quot;program&quot;&gt;\n          &lt;div class=&quot;program-index&quot;&gt;03&lt;\/div&gt;\n          &lt;div class=&quot;program-title&quot;&gt;\n            &lt;p class=&quot;program-kicker&quot;&gt;Translational path&lt;\/p&gt;\n            &lt;h3&gt;Experimental Development&lt;\/h3&gt;\n            &lt;span class=&quot;status-pill violet&quot;&gt;Clinical translation&lt;\/span&gt;\n          &lt;\/div&gt;\n          &lt;div class=&quot;program-body&quot;&gt;\n            &lt;p&gt;Experimental development now supports clinical translation. TR-002 is designated for clinical trials, while TR-003 is at the IND stage. Ongoing work integrates nanomedicine, medicinal chemistry, AI-informed prioritization and experimental evidence.&lt;\/p&gt;\n            &lt;p&gt;The company also reports development of a phototherapeutic nano-transformer with curative effects in cancer models.&lt;\/p&gt;\n          &lt;\/div&gt;\n          &lt;figure class=&quot;program-visual source-figure experimental-visual&quot;&gt;&lt;a href=&quot;https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-experimental-concept-18844f920b96.png&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot; aria-label=&quot;Open full-size experimental illustration&quot;&gt;&lt;img src=&quot;https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-experimental-concept-18844f920b96.png&quot; alt=&quot;Conceptual illustration of a clinical research conversation and adults sharing everyday activities in an accessible community setting; not a depiction of treatment outcomes.&quot; width=&quot;1672&quot; height=&quot;941&quot; loading=&quot;lazy&quot; decoding=&quot;async&quot;&gt;&lt;\/a&gt;&lt;\/figure&gt;\n        &lt;\/article&gt;\n      &lt;\/div&gt;\n    &lt;\/section&gt;\n\n    &lt;section class=&quot;section evidence&quot; id=&quot;evidence&quot; aria-labelledby=&quot;evidence-title&quot;&gt;\n      &lt;div class=&quot;container&quot; id=&quot;news&quot;&gt;\n        &lt;div class=&quot;section-heading&quot;&gt;\n          &lt;p class=&quot;eyebrow light&quot;&gt;Evidence &amp;amp; Updates&lt;\/p&gt;\n          &lt;h2 id=&quot;evidence-title&quot;&gt;Research evidence and company updates.&lt;\/h2&gt;\n        &lt;\/div&gt;\n        &lt;div class=&quot;evidence-grid&quot;&gt;\n          &lt;div class=&quot;evidence-main&quot;&gt;\n            &lt;h3&gt;Selected publications&lt;\/h3&gt;\n            &lt;ol class=&quot;publications&quot;&gt;\n              &lt;li&gt;\n                &lt;span class=&quot;publication-year&quot;&gt;2020&lt;\/span&gt;\n                &lt;p&gt;Ma et al. \u201cPharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy.\u201d &lt;em&gt;Nature Communications&lt;\/em&gt;, 11, Article 4615.&lt;\/p&gt;\n              &lt;\/li&gt;\n              &lt;li&gt;\n                &lt;span class=&quot;publication-year&quot;&gt;2022&lt;\/span&gt;\n                &lt;p&gt;Ma et al. \u201cA pH-Driven Small-Molecule Nanotransformer Hijacks Lysosomes and Overcomes Autophagy-Induced Resistance in Cancer.\u201d &lt;em&gt;Angewandte Chemie International Edition&lt;\/em&gt;, 61(35), e202204567.&lt;\/p&gt;\n              &lt;\/li&gt;\n              &lt;li&gt;\n                &lt;span class=&quot;publication-year&quot;&gt;2025&lt;\/span&gt;\n                &lt;p&gt;Tang M. \u201cMultifunctional and scalable nanoparticles for bimodal image-guided phototherapy in bladder cancer treatment.\u201d &lt;em&gt;Nano-Micro Letters&lt;\/em&gt;, 2025, 17(1), 222.&lt;\/p&gt;\n              &lt;\/li&gt;\n              &lt;li&gt;\n                &lt;span class=&quot;publication-year&quot;&gt;2026&lt;\/span&gt;\n                &lt;p&gt;Mahri S. \u201cTowards the clinical translation of a novel autophagy inhibitor: Bisaminoquinoline derivative nanoparticles.\u201d &lt;em&gt;Biomaterials&lt;\/em&gt;, 2026, 335, 124361.&lt;\/p&gt;\n              &lt;\/li&gt;\n            &lt;\/ol&gt;\n          &lt;\/div&gt;\n          &lt;div class=&quot;evidence-side&quot;&gt;\n            &lt;div class=&quot;fact-card&quot;&gt;\n              &lt;span&gt;Federal funding&lt;\/span&gt;\n              &lt;strong&gt;~$6M&lt;\/strong&gt;\n              &lt;p&gt;Multiple SBIR Phase I and Phase II grants.&lt;\/p&gt;\n            &lt;\/div&gt;\n            &lt;div class=&quot;fact-card&quot;&gt;\n              &lt;span&gt;Companion animals&lt;\/span&gt;\n              &lt;strong&gt;~$5.5M&lt;\/strong&gt;\n              &lt;p&gt;Research funding received through the laboratory to develop the approach in companion animals.&lt;\/p&gt;\n            &lt;\/div&gt;\n            &lt;div class=&quot;fact-card&quot;&gt;\n              &lt;span&gt;Patents&lt;\/span&gt;\n              &lt;strong&gt;Strong global IP portfolio&lt;\/strong&gt;\n              &lt;p&gt;The company reports patent protection covering chemical composition, nanoparticle technology and applications.&lt;\/p&gt;\n            &lt;\/div&gt;\n          &lt;\/div&gt;\n        &lt;\/div&gt;\n&lt;div class=&quot;pipeline-grid&quot; aria-label=&quot;Updated pipeline&quot;&gt;\n          &lt;article class=&quot;pipeline-card&quot;&gt;&lt;span&gt;TR-002&lt;\/span&gt;&lt;h3&gt;AiSN autophagy inhibitor&lt;\/h3&gt;&lt;p&gt;Pancreatic cancer \u00b7 Brain tumor&lt;\/p&gt;&lt;strong&gt;Clinical trials&lt;\/strong&gt;&lt;\/article&gt;\n          &lt;article class=&quot;pipeline-card&quot;&gt;&lt;span&gt;TR-003&lt;\/span&gt;&lt;h3&gt;TheraPBC autophagy inhibitor \/ photosensitizer&lt;\/h3&gt;&lt;p&gt;Phototherapeutic development&lt;\/p&gt;&lt;strong&gt;IND&lt;\/strong&gt;&lt;\/article&gt;\n        &lt;\/div&gt;\n                &lt;figure class=&quot;pipeline-figure&quot;&gt;\n          &lt;a href=&quot;https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-pipeline-updated-6f0153572763-1.png&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot; aria-label=&quot;Open full-size development pipeline&quot;&gt;&lt;img src=&quot;https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-pipeline-updated-6f0153572763-1.png&quot; alt=&quot;Theranostec development pipeline: TR-002 AiSN for pancreatic cancer and brain tumors at Clinical Trials; TR-003 TheraPBC for head and neck cancer and bladder cancer at IND. Stages are program-level.&quot; width=&quot;3000&quot; height=&quot;1688&quot; loading=&quot;lazy&quot; style=&quot;max-height:none;height:auto;&quot;&gt;&lt;\/a&gt;\n          \n        &lt;\/figure&gt;\n      &lt;\/div&gt;\n    &lt;\/section&gt;\n\n    &lt;section class=&quot;section people&quot; aria-labelledby=&quot;people-title&quot;&gt;\n      &lt;div class=&quot;container&quot;&gt;\n        &lt;div class=&quot;section-heading compact&quot;&gt;\n          &lt;p class=&quot;eyebrow&quot;&gt;Company&lt;\/p&gt;\n          &lt;h2 id=&quot;people-title&quot;&gt;Leadership and advisors&lt;\/h2&gt;\n        &lt;\/div&gt;\n        &lt;div class=&quot;people-grid&quot;&gt;\n          &lt;article class=&quot;person leader&quot;&gt;&lt;span&gt;Founder &amp;amp; CEO&lt;\/span&gt;&lt;h3&gt;Yuanpei Li, PhD&lt;\/h3&gt;&lt;p&gt;Professor at the University of California, Davis; elected Fellow of the American Institute for Medical and Biological Engineering; expert in cancer drug development, nanomedicine and cGMP production.&lt;\/p&gt;&lt;\/article&gt;\n          &lt;article class=&quot;person leader&quot;&gt;&lt;span&gt;Co-Founder &amp;amp; COO&lt;\/span&gt;&lt;h3&gt;Tzu-yin Cindy Lin, DVM, PhD, DACVP&lt;\/h3&gt;&lt;p&gt;Research associated Professor at the University of California, Davis; expert in translational cancer research, toxicology and clinical pathology, and nanomedicine.&lt;\/p&gt;&lt;\/article&gt;\n          &lt;article class=&quot;person&quot;&gt;&lt;span&gt;Advisor&lt;\/span&gt;&lt;h3&gt;Edward J. Kim, MD, PhD&lt;\/h3&gt;&lt;p&gt;Interim Chief, Division of Hematology and Oncology; Professor of Medicine; Ken and Cindy Blumenthal Endowed Professor for Pancreatic Cancer Research, UC Davis Comprehensive Cancer Center; Medical Director \u2013 UCDCCC-CTO (aka OCR); Medical Director \u2013 UC Davis Cancer Care Network.&lt;\/p&gt;&lt;\/article&gt;\n          &lt;article class=&quot;person&quot;&gt;&lt;span&gt;Advisor&lt;\/span&gt;&lt;h3&gt;Andrew C. Birkeland, MD&lt;\/h3&gt;&lt;p&gt;Surgeon-scientist in the Department of Otolaryngology-Head and Neck Surgery at the University of California, Davis; expert in head and neck cancer treatment and research.&lt;\/p&gt;&lt;\/article&gt;\n          &lt;article class=&quot;person&quot;&gt;&lt;span&gt;NIH CAP advisor&lt;\/span&gt;&lt;h3&gt;Dr. Rick Harkins&lt;\/h3&gt;&lt;p&gt;Former Principal Scientist at Bayer Healthcare, with 35 years of experience managing partnerships with U.S. academic institutions and emerging life-science firms.&lt;\/p&gt;&lt;\/article&gt;\n          &lt;article class=&quot;person&quot;&gt;&lt;span&gt;Advisor&lt;\/span&gt;&lt;h3&gt;Lloyd Kunimoto&lt;\/h3&gt;&lt;p&gt;CEO of Amfora, Inc., with 25 years of experience leading biotechnology and biopharmaceutical companies.&lt;\/p&gt;&lt;\/article&gt;\n        &lt;\/div&gt;\n      &lt;\/div&gt;\n    &lt;\/section&gt;\n\n    &lt;section class=&quot;partner&quot; id=&quot;contact&quot; aria-labelledby=&quot;partner-title&quot;&gt;\n      &lt;div class=&quot;container partner-grid&quot;&gt;\n        &lt;div&gt;\n          &lt;p class=&quot;eyebrow light&quot;&gt;Partner with us&lt;\/p&gt;\n          &lt;h2 id=&quot;partner-title&quot;&gt;Connect with Theranostec.&lt;\/h2&gt;\n          &lt;p&gt;For research and business inquiries, contact the company directly.&lt;\/p&gt;\n          &lt;a class=&quot;button button-primary&quot; href=&quot;mailto:yli@theranostec.com&quot;&gt;yli@theranostec.com&lt;\/a&gt;\n        &lt;\/div&gt;\n        &lt;address&gt;\n          &lt;span&gt;Theranostec, Inc.&lt;\/span&gt;\n          2700 Stockton Boulevard&lt;br&gt;\n          Sacramento, CA 95817&lt;br&gt;\n          &lt;a href=&quot;https:\/\/www.theranostec.com\/&quot;&gt;www.theranostec.com&lt;\/a&gt;\n        &lt;\/address&gt;\n      &lt;\/div&gt;\n    &lt;\/section&gt;\n  &lt;\/main&gt;\n\n  &lt;footer class=&quot;site-footer&quot;&gt;\n    &lt;div class=&quot;container footer-grid&quot;&gt;\n      &lt;span class=&quot;logo-window&quot;&gt;&lt;img src=&quot;https:\/\/www.theranostec.com\/wp-content\/uploads\/2026\/09\/theranostec-logo-user-20260908.png&quot; alt=&quot;Theranostec&quot; width=&quot;1942&quot; height=&quot;809&quot;&gt;&lt;\/span&gt;\n      &lt;p&gt;Precision nanomedicine for cancer therapy.&lt;\/p&gt;\n      &lt;p&gt;\u00a9 &lt;span data-year&gt;2026&lt;\/span&gt; Theranostec, Inc.&lt;\/p&gt;\n    &lt;\/div&gt;\n  &lt;\/footer&gt;\n&lt;script&gt;(() =&gt; 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